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Published on: April 23, 2019
Self-poisoning with lamotrigine and pregabalin
1Department of Anaesthetics and Intensive Care, Gloucestershire Royal Hospital, Gloucester, UK. alicebraga@doctors.org.uk
Anaesthesia
|April 24, 2007
Summary
This case report details an intentional overdose of lamotrigine and pregabalin, featuring the highest recorded lamotrigine plasma levels. Management focused on supportive care for seizures and altered consciousness.
Area of Science:
- Clinical Toxicology
- Neuropharmacology
Background:
- Newer anti-epileptic drugs (AEDs) like lamotrigine and pregabalin are increasingly used for seizure disorders.
- Understanding the toxicological profiles of these agents, especially in overdose, is crucial for clinical management.
Observation:
- A 29-year-old male intentionally overdosed on lamotrigine and pregabalin.
- The patient presented with significant clinical manifestations including seizures and reduced level of consciousness.
Findings:
- This case documents the highest plasma lamotrigine levels reported in medical literature.
- The overdose resulted in severe neurological symptoms requiring intensive care.
Implications:
- This report highlights the potential for severe toxicity with combined lamotrigine and pregabalin overdose.
- It underscores the importance of vigilant monitoring and supportive care in managing such overdoses.
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