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Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis

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Candida albicans does not invade carious human dentine.

M Maijala¹, R Rautemaa, A Järvensivu

¹Institute of Dentistry, University of Helsinki, Helsinki, Finland.

|April 24, 2007

Summary

This study found Candida albicans is not a significant factor in dentinal caries progression. Immunohistochemistry showed minimal yeast presence, questioning its role as a caries pathogen.

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A Catheter-Related Candida albicans Infection Model in Mouse

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Published on: March 22, 2024

Area of Science:

Microbiology
Dental Pathology
Immunohistochemistry

Background:

Candida albicans is a yeast that has been implicated as a potential dental caries pathogen.
Evidence supporting the specific role of Candida albicans in caries progression remains limited.
Significant yeast presence within a lesion is considered a prerequisite for its role in caries pathology.

Purpose of the Study:

To investigate the presence and extent of Candida albicans in human dentinal caries lesions.
To evaluate the suitability of different staining methods for detecting yeasts in carious dentin.

Main Methods:

Human carious teeth (n=10) were sectioned and stained using Gram, Giemsa, Periodic Acid-Schiff (PAS), and immunohistochemistry with a Candida albicans-specific antibody.
A total of 120 sections were analyzed across the different staining techniques.

Main Results:

Extensive bacterial invasion and positive PAS staining were observed in all samples.
Immunohistochemistry detected only a few weakly positive sections (3.3%) with minimal Candida albicans cells on the lesion surface.
Positive identification of Candida albicans based on cell morphology was not achievable.

Conclusions:

The findings do not support the hypothesis that Candida albicans plays a significant role in dentinal caries pathology.
Periodic Acid-Schiff (PAS) staining demonstrated an unspecific nature and was deemed unsuitable for detecting yeasts in carious tooth samples.