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Applications Of NMR In Biology

Applications Of NMR In Biology

Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
The...

Nuclear Magnetic Resonance (NMR): Overview

Nuclear Magnetic Resonance (NMR): Overview

Nuclear magnetic resonance (NMR) is a phenomenon exhibited by certain nuclei that can absorb characteristic radio frequency radiation under certain conditions. NMR has been extensively applied in molecular spectroscopy and medical diagnostic imaging. In both these applications, the molecule or subject under study is placed in a magnetic field and irradiated with radio frequency energy.
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...

NMR Spectrometers: Resolution and Error Correction

NMR Spectrometers: Resolution and Error Correction

When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...

NMR Spectrometers: Overview

NMR Spectrometers: Overview

NMR spectrometers consist of a strong magnet, a radiofrequency transmitter, and a detector attached to a computer console for recording spectra of samples containing NMR-active nuclei. In first-generation NMR instruments called continuous-wave spectrometers, the resonance frequencies of the nuclei are determined by frequency-sweep or field-sweep methods. The magnetic field strength is fixed and the rf signal is swept in the former, while the radiofrequency signal is fixed and the magnetic field...

NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences

NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences

A pulse is a short burst of radio waves distributed over a range of frequencies that simultaneously excites all the nuclei in the sample. Upon passing a radio frequency pulse along the x-axis, the nuclei absorb energy corresponding to their Larmor frequencies and achieve resonance. This shifts the net magnetization vector from the z-axis toward the transverse plane. This angle of rotation of the magnetization vector, or the flip angle, is proportional to the duration and intensity of the pulse.

Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Related Experiment Video

Updated: Jul 15, 2026

Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins

Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins

Published on: September 23, 2021

matNMR: a flexible toolbox for processing, analyzing and visualizing magnetic resonance data in Matlab.

Jacco D van Beek¹

¹Physical Chemistry, ETH Zurich, CH-8093 Zurich, Switzerland. jabe@nwr.phys.chem.ethz.ch

Journal of Magnetic Resonance (San Diego, Calif. : 1997)

|April 24, 2007

Summary

matNMR is a versatile MATLAB toolbox for magnetic-resonance data processing and analysis. It offers both graphical and script-based interfaces for enhanced control and flexibility in research.

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Area of Science:

Chemistry
Physics
Biophysics

Background:

Magnetic resonance (MR) research requires sophisticated tools for data processing and analysis.
Existing software may lack the flexibility and control needed for complex MR studies.
MATLAB is a widely used environment for scientific computation and data visualization.

Purpose of the Study:

To introduce matNMR, a new toolbox for processing, analyzing, and visualizing magnetic-resonance data.
To provide a flexible and extensible platform for modern MR research within MATLAB.
To enable both graphical user interface (GUI) and command-line script-based operations.

Main Methods:

Development of a toolbox named matNMR within the MATLAB environment.
Implementation of both GUI and command-line script options for data processing.
Leveraging MATLAB's extensive mathematical and visualization routines for MR data.
Allowing incorporation of user-defined processing and analysis functions.

Main Results:

matNMR provides a high degree of control and flexibility for MR data analysis.
The toolbox supports both interactive (GUI) and automated (script) processing workflows.
Direct access to data points during processing is facilitated.
Extensive mathematical and visualization capabilities are integrated.

Conclusions:

matNMR offers a powerful and adaptable solution for magnetic-resonance data processing and analysis.
The toolbox enhances research capabilities by providing control, flexibility, and extendability.
It is suitable for various modern magnetic-resonance research applications.