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Targeting the sticky fingers of HIV-1
Robert Blumenthal1, Dimiter S Dimitrov
1Center for Cancer Research Nanobiology Program, NCI-Frederick, NIH, Frederick, MD 21702-1201, USA. blumen@helix.nih.gov
Abstract:
Although human blood plasma contains molecules that inhibit the activity of HIV-1, their identity is largely unknown. Münch et al. (2007) now identify a peptide corresponding to a portion of alpha1-antitrypsin that potently inhibits entry of HIV-1 into host cells by binding to a hydrophobic segment of the viral envelope glycoprotein gp41.
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