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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Improvement in diastolic function and left ventricular filling pressure induced by cardiac resynchronization therapy

Annemieke H M Jansen1, Jan melle van Dantzig, Frank Bracke

  • 1Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands. annemieke.jansen@cze.nl

American Heart Journal
|April 25, 2007
PubMed

Insights

Cardiac resynchronization therapy (CRT) improves diastolic function and filling pressures, but left ventricular (LV) reverse remodeling is essential for sustained benefits. LV dyssynchrony predicts this remodeling, crucial for long-term improvement.

Area of Science:

  • Cardiology
  • Cardiac Electrophysiology
  • Heart Failure Management

Background:

  • Cardiac resynchronization therapy (CRT) shows variable effects on diastolic function.
  • Investigating the impact of CRT on diastolic function, left ventricular (LV) filling pressures, and LV reverse remodeling over 3 and 12 months.

Purpose of the Study:

  • To evaluate the effect of CRT on diastolic function and LV filling pressures.
  • To determine the relationship between CRT-induced LV reverse remodeling and improvements in diastolic function and filling pressures.

Main Methods:

  • Echocardiography and Doppler measurements in 52 patients before and 3/12 months after CRT.
  • Tissue Doppler and color M-mode utilized to estimate LV filling pressures (E/Em, E/Vp ratios).

Main Results:

  • 58% of patients achieved LV reverse remodeling after 12 months.
  • LV dyssynchrony, not baseline diastolic function, predicted LV reverse remodeling.
  • Diastolic function improved significantly in patients with LV reverse remodeling; filling pressures decreased significantly only in this group.

Conclusions:

  • CRT-induced LV reverse remodeling is associated with improved diastolic function and LV filling pressures.
  • While short-term benefits correlate with reduced filling pressures, LV reverse remodeling is mandatory for sustained, long-term improvement.
Abstract

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