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Comparative Lesions Analysis Through a Targeted Sequencing Approach
Published on: November 5, 2019
Trisomy 7 in postoperative spindle cell nodules
Francesca Micci1, Lisbeth Haugom, Vera M Abeler
1Department of Medical Genetics, Rikshospitalet-Radiumhospitalet Medical Centre, Ullernchaussen 70, 0310 Oslo, Norway. francesca.micci@labmed.uio.no <francesca.micci@labmed.uio.no>
Cancer Genetics and Cytogenetics
|April 25, 2007
Summary
Postoperative spindle cell nodules, a benign lesion mimicking sarcoma, were analyzed. Trisomy 7 was the sole genetic abnormality found in both vulvar and bladder lesions, suggesting a consistent cytogenetic finding.
Area of Science:
- Surgical Pathology
- Cytogenetics
- Oncology
Background:
- Postoperative spindle cell nodule (PSCN) is a reactive lesion that can mimic malignancy.
- PSCNs typically arise after surgery and are considered benign with no reported recurrences.
Observation:
- Two cases of PSCN, one in the vulva and one in the urinary bladder, were examined.
- Cytogenetic analysis was performed on both lesions.
Findings:
- Trisomy 7 was identified as the sole karyotypic abnormality in the vulvar PSCN.
- Interphase fluorescence in situ hybridization (FISH) confirmed trisomy 7 in the urinary bladder PSCN.
Implications:
- The consistent finding of trisomy 7 in PSCN suggests a potential role in the lesion's pathogenesis.
- This cytogenetic finding may aid in differentiating PSCN from true neoplasms like leiomyosarcoma.
- Further research is warranted to understand the significance of trisomy 7 in reactive spindle cell lesions.
