Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Visual loss in tuberous sclerosis.

S A Dotan1, J D Trobe, S S Gebarski

  • 1W.K. Kellogg Eye Center, Department of Ophthalmology, University of Michigan Medical Center, Ann Arbor.

Neurology
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serous retinal detachment in hypertensive posterior reversible encephalopathy syndrome.

AJNR. American journal of neuroradiology·2011
Same author

Massive symptomatic subependymoma of the lateral ventricles: case report and review of the literature.

Neuroradiology·2005
Same author

The Fifth European Neuro-Ophthalmological Society (EUNOS) meeting, Tübingen, Germany, July 22-26, 2001.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2002
Same author

Penetrating orbital injury by automobile wiper-control stalk.

Archives of ophthalmology (Chicago, Ill. : 1960)·2000
Same author

Common errors in the use of magnetic resonance imaging for neuro-ophthalmic diagnosis.

Survey of ophthalmology·2000
Same author

Audiovestibular phenotype associated with a COL11A1 mutation in Marshall syndrome.

Archives of otolaryngology--head & neck surgery·2000
Same journal

Factors Associated With Disability Improvement and Worsening Independent of Attacks in Patients With AQP4-IgG+ NMOSD and MOGAD: A Multicenter Cohort Study.

Neurology·2026
Same journal

Cost-Effectiveness of Intracranial Aneurysm Screening: A Systematic Review.

Neurology·2026
Same journal

Rare Eating Epilepsy: Co-Occurrence of Focal Cortical Dysplasia and Gray Matter Heterotopia.

Neurology·2026
Same journal

Spatiotemporal Associations Between Cortical Microinfarcts and Cortical Superficial Siderosis in Cerebral Amyloid Angiopathy.

Neurology·2026
Same journal

Blood-Brain Barrier Disruption Before Interhospital Transfer for Thrombectomy and Clinical Outcome.

Neurology·2026
Same journal

At Death's Door: Cytosolic Dopamine in Patients With Parkinson Disease.

Neurology·2026
See all related articles

Tuberous Sclerosis Complex (TSC) patients with obstructive hydrocephalus face serious visual risks. Early ophthalmologic exams and brain imaging are crucial for subependymal lesions to prevent irreversible vision loss.

Area of Science:

  • Neuro-oncology
  • Ophthalmology

Background:

  • Tuberous Sclerosis Complex (TSC) is a genetic disorder that can cause tumors to grow in various organs, including the brain.
  • Subependymal giant-cell astrocytomas can lead to obstructive hydrocephalus, increasing intracranial pressure.
  • Hydrocephalus in TSC, while uncommon, poses significant risks to visual function.

Observation:

  • Eleven patients with TSC and obstructive hydrocephalus secondary to subependymal giant-cell astrocytoma were evaluated between 1980 and 1990.
  • Visual outcomes were documented in four patients following surgical relief of elevated intracranial pressure.

Findings:

  • Despite surgical intervention, two patients experienced further visual loss.
  • One patient achieved arrest of visual loss, and another had visual loss prevented.

Related Experiment Videos

  • The effects of hydrocephalus on optic nerves in TSC are serious and potentially irreversible.

    • Implications:

    • Patients with TSC and identified subependymal lesions require vigilant monitoring.
    • Periodic ophthalmologic examinations and brain imaging are recommended to detect and manage increased intracranial pressure.
    • Prompt intervention may help prevent or mitigate severe visual impairment in TSC patients.