Efficient co-crystal screening using solution-mediated phase transformation.

Area of Science:

• Solid-state chemistry and pharmaceutical science.

Background:

• Established physical stability treatments for hydrates/solvates are extended to co-crystals.
• Co-crystallization is a key strategy for modifying pharmaceutical solid-state properties.

Discussion:

• A novel suspension/slurry screening technique is developed based on the extended physical stability treatment.
• This technique was successfully validated across sixteen diverse pharmaceutical co-crystal systems.

Key Insights:

• The proposed theoretical treatment provides a framework for understanding co-crystal physical stability.
• The practical screening technique enhances the efficiency of identifying stable co-crystal forms.

Outlook:

• This work offers valuable tools for researchers in pharmaceutical co-crystallization.