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Updated: Jul 15, 2026
Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
[Multifocal oscillatory potentials (mfOPs) in patients with central retinal vein occlusion]
Joanna A Stepień1, Herbert Jagle, Anne Kurtenbach
1Kliniki Okulistycznej Uniwersytetu w Tybindze, Niemczech.
Purpose:
To evaluate usefulness of multifocal oscillatory potentials (mfOPs) in diagnostics in patients with retinal vein occlusions.
Material And Methods:
The Visual Evoked Imaging System (VERIS, version 4.9) was used to stimulate the visual system to elicit mfOPs from 103 areas subtending the central 70-80 degrees of the retina in three patients with central or branch retinal vein occlusions. Two stimulating conditions were used. For each subject, the mean first- and second-order kernel responses from occlusion area, were analyzed and compared with the fellow eye and control subjects results.
Results:
In retinal areas without circulatory disturbances in fluorescein angiography all mfOPs components were present. In a patient with branch retinal vein occlusion in the area without capillary perfusion mfOPs responses were not detectable.
Conclusions:
The mfOPs are in a large extent dependent on a proper retinal circulation. The recording of mfOPs may be useful in clinical diagnosis, to asses circulatory disturbances in internal layers of the retina and in differentiation of ischemic from non ischemic retinal vein occlusions.
