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Clinical syndromes with variable pathologic features.

Frederick T Kraus1

  • 1Washington University Medical School, Department of OB-GYN, Campus Box 8064, St. Louis, MO 63110, USA. krausf@wudosis.wustl.edu

Seminars in Diagnostic Pathology
|April 26, 2007
PubMed
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This guide assists pathologists in identifying specific placental lesions associated with conditions like neonatal encephalopathy and fetal growth restriction. It aims to improve diagnostic accuracy for common pregnancy complications.

Area of Science:

  • Pathology
  • Obstetrics
  • Neonatology

Background:

  • Clinical diagnoses for placental examination often lack specificity.
  • Less experienced pathologists may require guidance in identifying placental lesions.
  • Accurate placental examination is crucial for understanding fetal and neonatal outcomes.

Purpose of the Study:

  • To provide a framework for placental examination when clinical diagnoses are non-specific.
  • To define conditions associated with specific placental lesions.
  • To assist pathologists in identifying relevant pathologic findings.

Main Methods:

  • Review of clinical conditions linked to placental pathology.
  • Development of a list of placental lesions for consideration.

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  • Emphasis on directed placental examination to identify specific lesions.

    • Main Results:

    • Identified key placental lesions associated with neonatal encephalopathy, preterm birth, fetal growth restriction, maternal diabetes mellitus, thrombophilias, HELLP syndrome, and fetal hydrops.
    • Outlined a systematic approach to placental examination for these conditions.

    Conclusions:

    • A structured approach to placental examination improves the identification of lesions relevant to specific clinical conditions.
    • This guide aids pathologists in diagnosing conditions affecting pregnancy outcomes.
    • Accurate placental pathology reporting is essential for clinical management and research.