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Disorders of Leukocytes

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Updated: Jul 15, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

Aleukemic leukemia cutis.

Vishwanath Vishalakshi¹, R G Torsekar, Santosh Shinde

¹Department of Dermatology, Rajiv Gandhi Medical College and Chhatrapati Shivaji Maharaj Hospital, Kalwa, Thane-400605, Maharashtra, India. vish@roltanet.com

Indian Journal of Dermatology, Venereology and Leprology

|April 26, 2007

Summary

Aleukemic leukemia cutis, a rare skin infiltration by leukemic cells, presented as myeloid sarcoma in a young man. Despite normal blood counts, the condition proved fatal within three months.

Area of Science:

Dermatology
Hematology
Oncology

Background:

Aleukemic leukemia cutis is a rare dermatological condition involving leukemic cell infiltration of the skin.
It precedes the detection of leukemic cells in peripheral blood or bone marrow.

Observation:

A 20-year-old male presented with a 6-month history of nodular scalp swelling and cervical lymphadenopathy.
Initial diagnostic workup, including peripheral blood counts and bone marrow examinations, showed no evidence of leukemia.

Findings:

Biopsy and immunohistochemistry confirmed the diagnosis of myeloid sarcoma.
The patient's presentation was characterized by aleukemic leukemia cutis.

Implications:

This case highlights the diagnostic challenge of aleukemic leukemia cutis.

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Last Updated: Jul 15, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

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Published on: March 26, 2018

Despite an initial aleukemic state, the prognosis can be rapidly fatal, emphasizing the need for prompt diagnosis and management.