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T1-weighted magnetic resonance imaging shows fatty deposition after myocardial infarction

James W Goldfarb1, Sheeba Arnold, Marguerite Roth

  • 1Department of Research and Education, Saint Francis Hospital, Roslyn, New York 11576, USA. James.Goldfarb@chsli.org

Magnetic Resonance in Medicine
|April 26, 2007
PubMed

Insights

Precontrast T1-weighted MRI can detect fat in myocardial infarction (MI) areas, helping determine the age of the heart attack. This noninvasive technique shows promise for assessing chronic MI and infarct age.

Area of Science:

  • Cardiovascular Imaging
  • Magnetic Resonance Imaging
  • Pathology

Background:

  • Pathologic studies reveal increased lipid content in myocardial infarction (MI) regions.
  • Noninvasive detection of fat deposition in MI is crucial for understanding infarct progression.

Purpose of the Study:

  • To evaluate precontrast T1-weighted MRI for detecting myocardial fat in MI.
  • To assess the association between fat deposition and infarct age using MRI.

Main Methods:

  • Thirty-two patients with MI underwent precontrast inversion-recovery (IR) cine steady-state free precession (SSFP) imaging.
  • Fat- and muscle-nulled images were generated to identify myocardial fat deposition.
  • Postcontrast delayed hyperenhanced (DHE) imaging was performed for comparison.

Main Results:

  • A significant association was found between infarct age and image contrast in both fat- and muscle-nulled images.
  • Precontrast MRI effectively located areas of fat deposition in the left ventricular (LV) myocardium.
  • Image contrast correlated with infarct age in MI regions.

Conclusions:

  • Precontrast T1-weighted MRI is a promising noninvasive method for detecting myocardial fat in chronic MI.
  • This MRI technique can be utilized to assess myocardial infarct age.
  • Fat deposition detection via MRI aids in characterizing chronic myocardial infarction.

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