Interface interactions of osteoblasts with structured titanium and the correlation between physicochemical characteristics and cell biological parameters
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Updated: Jul 15, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
J G Barbara Nebe1, Frank Luethen, Regina Lange
1Department of Internal Medicine, University of Rostock, BMFZ, Schillingallee 69, D-18057 Rostock, Germany. barbara.nebe@med.uni-rostock.de
Abstract:
Cellular behavior at the interface of an implant is influenced by the material's topography. However, little is known about the correlation between the biological parameters and the physicochemical characteristics of the biomaterial. We therefore modified pure titanium surfaces by polishing, machining, blasting with glass spheres, blasting with corundum particles, and vacuum plasma spraying to give progressively higher surface roughness. The material surface was characterized by SEM, surface profiling, and electrochemical methods. We revealed a correlation for integrin expression and formation, adhesion, spreading, proliferation, and bone sialo protein expression with the physicochemical parameters of the titanium surfaces.
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