Related Experiment Video
Updated: Jul 15, 2026
06:19
Intracameral Injection in Rats with Low Risk of Adverse Effects
Published on: May 31, 2024
Subconjunctival bevacizumab for corneal neovascularization
1Department of Ophthalmology, Fatih University Medical School, Alparslan Turkes Cad No: 57, 06510 Emek, Ankara, Turkey. merdurmus@yahoo.com
Summary
Subconjunctival bevacizumab injections effectively reduced corneal neovascularization (NV) in patients with dry eye and graft failure. This treatment shows promise for managing complex corneal NV cases.
Area of Science:
- Ophthalmology
- Vascular Biology
Background:
- Corneal neovascularization (NV) poses a significant challenge in managing ocular surface diseases.
- Current treatments for corneal NV have limitations, necessitating novel therapeutic strategies.
Observation:
- A retrospective case study examined two patients with corneal NV.
- Patients received subconjunctival injections of bevacizumab (2.5 mg).
- Morphologic changes were assessed via slit-lamp biomicroscopy and corneal photography.
Findings:
- Dramatic regression of corneal NV was observed within one week in a patient with dry eye and filamentary keratitis.
- Partial regression of major and minor corneal vessels occurred in a patient with corneal graft failure.
- No adverse events such as infection or inflammation were reported.
- No relapse of corneal NV was noted during a two-to-three-month follow-up period.
Implications:
- Subconjunctival bevacizumab injection presents a potential new treatment option for corneal neovascularization.
- This approach may be beneficial in managing challenging cases of corneal NV, including those associated with dry eye and graft failure.
Related Concept Videos
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...