Related Experiment Video
Updated: Jul 15, 2026

08:41
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
Severe acute respiratory syndrome (SARS) coronavirus
Matthew P Muller1, Allison McGeer
1Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, Canada.
Seminars in Respiratory and Critical Care Medicine
|April 27, 2007
Summary
Another severe acute respiratory syndrome (SARS) pandemic is possible due to its animal reservoir origins. This review covers SARS epidemiology, clinical features, diagnosis, and management strategies.
Area of Science:
- * Infectious Diseases
- * Epidemiology
- * Public Health
Background:
- * The 21st century's first pandemic, severe acute respiratory syndrome (SARS), was successfully contained.
- * Evidence suggests SARS originated in an animal reservoir, posing a risk for future pandemics.
Purpose of the Study:
- * To review the likelihood of another SARS pandemic.
- * To summarize the epidemiological and clinical characteristics of SARS.
- * To emphasize clinical presentation, diagnosis, and management.
Main Methods:
- * Literature review of epidemiological and clinical data.
- * Analysis of SARS outbreak information.
- * Synthesis of current knowledge on SARS.
Main Results:
- * The animal reservoir for SARS indicates a persistent risk of re-emergence.
- * Understanding SARS's clinical and epidemiological features is crucial for preparedness.
- * Effective diagnosis and management strategies are vital for control.
Conclusions:
- * The potential for another SARS pandemic remains a significant public health concern.
- * Continued surveillance and research into SARS origins and transmission are necessary.
- * Preparedness strategies should incorporate lessons learned from the initial outbreak.
Related Concept Videos
Coronavirus
Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...
Respiratory Syncytial Virus Disease
Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Acute Respiratory Failure-I
Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Acute Respiratory Failure-V
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Acute Respiratory Failure-II
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Rabies
Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...
