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Related Concept Videos

Fluid Movement Between Compartments01:18

Fluid Movement Between Compartments

The force applied by fluids against a surface, known as hydrostatic pressure, initiates the transfer of fluid among different compartments. Within our blood vessels, the blood's hydrostatic pressure is a result of the heart's pumping action. At the arteriolar end of capillaries, hydrostatic pressure (capillary blood pressure) exceeds the opposing colloid osmotic pressure created primarily by plasma proteins like albumin. This discrepancy in pressure propels plasma and nutrients from the...
Laminar and Turbulent Flow01:07

Laminar and Turbulent Flow

Fluid dynamics is the study of fluids in motion. Velocity vectors are often used to illustrate fluid motion in applications like meteorology. For example, wind—the fluid motion of air in the atmosphere—can be represented by vectors indicating the speed and direction of the wind at any given point on a map. Another method for representing fluid motion is a streamline. A streamline represents the path of a small volume of fluid as it flows. When the flow pattern changes with time, the streamlines...
Steady Flow of a Fluid Stream01:27

Steady Flow of a Fluid Stream

Consider a control volume, such as a pipe with solid boundaries, through which fluid flows and changes direction due to the impulse exerted by the resulting force from the pipe walls. In steady flow, the mass of fluid entering the control volume at a given time, t, with velocity v1, is equal to the mass leaving after infinitesimal time dt, with velocity v2.
During this process, the momentum of the fluid within the control volume remains constant over the time interval dt. By applying the...
Blood Flow01:29

Blood Flow

Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
Capillary Exchange01:28

Capillary Exchange

The cardiovascular system's chief role is to disseminate gases, nutrients, waste, and other substances to the body's cells. Small molecules like gases, lipids, and lipid-soluble substances directly diffuse through capillary wall endothelial cell membranes. Glucose, amino acids, and ions, including sodium, potassium, calcium, and chloride, use transporters for facilitated diffusion via membrane-specific channels. Glucose, ions, and bigger molecules may also pass through intercellular clefts.
Applications of Integration to Find Blood Flow01:27

Applications of Integration to Find Blood Flow

Blood flow through a cylindrical blood vessel can be mathematically described using the principles of laminar flow, a regime in which fluid moves smoothly in parallel layers. In this model, the velocity of the blood is not uniform across the cross-section of the vessel; rather, it varies with the radial distance from the center. The maximum velocity occurs along the central axis, decreasing progressively toward the vessel walls, where it reaches zero due to viscous drag.Approximating Blood...

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Related Experiment Video

Updated: Jul 15, 2026

Three-dimensional Cell Culture Model for Measuring the Effects of Interstitial Fluid Flow on Tumor Cell Invasion
07:41

Three-dimensional Cell Culture Model for Measuring the Effects of Interstitial Fluid Flow on Tumor Cell Invasion

Published on: July 25, 2012

Interstitial flow and its effects in soft tissues.

Melody A Swartz1, Mark E Fleury

  • 1Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Switzerland. melody.swartz@epfl.ch

Annual Review of Biomedical Engineering
|April 27, 2007
PubMed
Summary

Interstitial flow is vital for tissue development and health. Understanding fluid transport in tissues is key for tissue engineering and improving drug delivery methods.

Area of Science:

  • Biomedical Engineering
  • Physiology
  • Biophysics

Background:

  • Interstitial flow significantly influences tissue morphogenesis, function, and disease.
  • The interstitial space's role in controlling these processes requires thorough investigation.
  • Understanding interstitial transport is crucial for advancements in tissue engineering and drug delivery.

Purpose of the Study:

  • To review physical and mathematical models of fluid and mass transport in the tissue interstitium.
  • To identify factors influencing interstitial transport.
  • To discuss the implications of interstitial transport in cell biology, tissue engineering, and drug delivery.

Main Methods:

  • Literature review of physical and mathematical correlations.
  • Analysis of factors affecting fluid and mass transport.

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Spatial Temporal Analysis of Fieldwise Flow in Microvasculature
09:39

Spatial Temporal Analysis of Fieldwise Flow in Microvasculature

Published on: November 18, 2019

Related Experiment Videos

Last Updated: Jul 15, 2026

Three-dimensional Cell Culture Model for Measuring the Effects of Interstitial Fluid Flow on Tumor Cell Invasion
07:41

Three-dimensional Cell Culture Model for Measuring the Effects of Interstitial Fluid Flow on Tumor Cell Invasion

Published on: July 25, 2012

Spatial Temporal Analysis of Fieldwise Flow in Microvasculature
09:39

Spatial Temporal Analysis of Fieldwise Flow in Microvasculature

Published on: November 18, 2019

  • Discussion of implications for various biological and medical applications.

    • Main Results:

    • Physical and mathematical correlations governing interstitial transport were reviewed.
    • Key factors influencing interstitial fluid and mass transport were identified.
    • The importance of interstitial transport in cell biology, tissue engineering, and drug delivery was highlighted.

    Conclusions:

    • A comprehensive understanding of interstitial transport is critical for tissue engineering and drug delivery.
    • Interstitial flow impacts cell biology, tissue development, and disease pathogenesis.
    • Further research into interstitial transport can address challenges in drug delivery, cell mechanobiology, and lymphatic homing.