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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

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Related Experiment Video

Updated: Jul 15, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Bone metabolism and new targets for intervention.

Bulent Akduman1, E David Crawford

  • 1Department of Urology, School of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey. akdumanb@yahoo.com

Current Urology Reports
|April 27, 2007
PubMed
Summary

Prostate cancer commonly spreads to bone, causing significant patient morbidity. This review discusses bone metabolism, cancer metastasis, and targeted treatments for advanced prostate cancer.

Area of Science:

  • Oncology
  • Metastasis Research
  • Bone Biology

Background:

  • Bone metastasis is a frequent and debilitating complication of advanced prostate cancer.
  • Prostate cancer bone metastasis involves intricate interactions between cancer cells and the bone microenvironment.
  • Understanding these interactions is crucial for developing effective therapeutic strategies.

Purpose of the Study:

  • To review the complex processes of bone metabolism and prostate cancer metastasis to bone.
  • To highlight the role of host cell and cancer cell interactions in organ-specific progression.
  • To discuss current and emerging targeted therapies for advanced prostate cancer with bone metastasis.

Main Methods:

  • Literature review of bone metabolism in prostate cancer.

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Osteoclast Derivation from Mouse Bone Marrow
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Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Related Experiment Videos

Last Updated: Jul 15, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

  • Analysis of host-tumor interactions in bone metastasis.
  • Discussion of targeted treatment strategies for advanced prostate cancer.

    • Main Results:

    • Bone metastasis significantly increases patient morbidity in prostate cancer.
    • Prostate cancer progression in bone is driven by complex cellular interactions.
    • Targeted therapies offer promising new avenues for treating advanced disease.

    Conclusions:

    • Effective management of prostate cancer bone metastasis requires understanding bone metabolism and cellular interactions.
    • Targeted therapies are increasingly important for advanced prostate cancer treatment.
    • Further research into these areas can improve patient outcomes.