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CINRG pilot trial of oxatomide in steroid-naïve Duchenne muscular dystrophy

Gunnar M Buyse1, Nathalie Goemans, Erik Henricson

  • 1University Hospitals KU Leuven, Leuven, Herestraat 49, B-3000 Leuven, Belgium. gunnar.buyse@uz.kuleuven.ac.be

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
|April 27, 2007
PubMed

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...