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Updated: Jul 15, 2026
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Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy
Published on: September 27, 2021
[Preoperatively administered flomoxef sodium concentration in aqueous humor]
Mariko Miyamoto1, Yoichiro Watanabe, Nobuhisa Mizuki
1Department of Ophthalmology, Kanazawa Hospital, Tokyo, Japan. m4429jp@yahoo.co.jp
Nippon Ganka Gakkai Zasshi
|April 28, 2007
Summary
Flomoxef sodium (FMOX) administered intravenously before cataract surgery achieved adequate aqueous humor concentrations to combat common bacteria. This suggests FMOX may effectively prevent postoperative endophthalmitis.
Area of Science:
- Ophthalmology
- Pharmacology
- Infectious Disease
Context:
- Cataract surgery is a common procedure with a risk of postoperative endophthalmitis.
- Endophthalmitis prevention is crucial for maintaining visual outcomes.
- Antibiotic penetration into the aqueous humor is key for prophylaxis.
Purpose:
- To evaluate the penetration of flomoxef sodium (FMOX) into the aqueous humor.
- To determine the efficacy of FMOX in preventing postoperative endophthalmitis after cataract surgery.
- To measure FMOX concentrations in aqueous humor at various pre-operative time points.
Summary:
- Flomoxef sodium (FMOX) was administered intravenously to 56 patients undergoing cataract surgery.
- Aqueous humor FMOX concentrations were measured using high-performance liquid chromatography.
- Concentrations achieved 0.5-3.0 hours pre-operatively exceeded MIC90 for common causative agents like S. epidermidis and S. aureus.
Impact:
- Intraoperative FMOX levels in aqueous humor were sufficient to inhibit the growth of key bacteria in vitro.
- FMOX demonstrates potential as an effective prophylactic agent against postoperative endophthalmitis.
- Further clinical studies are warranted to confirm the prophylactic efficacy of FMOX in cataract surgery patients.
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