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Updated: Jul 15, 2026
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Mutual interference between serum thyroglobulin and antithyroglobulin antibody in an automated chemiluminescent
Yunchao Gao1, Zhibin Yuan, Yongli Yu
1The Immunoassay Laboratory, Department of Nuclear Medicine, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China. gaookok@163.com
Objectives:
To investigate the analytical interference between serum Tg and TgAb.
Design And Methods:
Tg and TgAb were measured on an automated chemiluminescent immunoassay system in mixed sera from DTC patients and individual samples spiked with exogenous Tg.
Results:
Tg and TgAb recoveries in mixed patient samples were inversely correlated with expected TgAb or Tg concentrations, respectively. Impaired TgAb recoveries were also found in 50% (10/20) samples with high Tg in the exogenous recovery tests.
Conclusions:
Mutual but not equal analytical interference between Tg and TgAb is present and concentration-dependent with interpatient variability.
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