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DITOP: drug-induced toxicity related protein database
Jing-Xian Zhang1, Wei-Juan Huang, Jing-Hua Zeng
1Key Laboratory for Cell Biology & Tumor Cell Engineering, the Ministry of Education of China, School of Life Sciences, Xiamen University, Xiamen 361005, FuJian, PR China.
Bioinformatics (Oxford, England)
|April 28, 2007
Summary
The Drug-Induced Toxicity Related Protein database (DITOP) catalogs proteins mediating adverse drug reactions. This resource aids understanding of drug toxicity mechanisms and supports rational drug discovery.
Area of Science:
- Biochemistry
- Pharmacology
- Bioinformatics
Background:
- Drug-induced toxicity related proteins (DITRPs) mediate adverse drug reactions (ADRs) by interacting with drugs or their metabolites.
- Understanding DITRPs is crucial for elucidating drug toxicity mechanisms and advancing rational drug discovery.
- The Drug-Induced Toxicity Related Protein database (DITOP) aims to consolidate information on these critical proteins.
Purpose of the Study:
- To establish a comprehensive database (DITOP) for drug-induced toxicity related proteins (DITRPs).
- To facilitate research into the molecular mechanisms of drug-induced toxicity and adverse drug reactions.
- To provide a user-friendly platform for accessing and retrieving DITRP information.
Main Methods:
- Compilation of literature-reported DITRPs and their associated drugs, ligands, and toxicity terms.
- Inclusion of five major types of drug-induced toxicities: idiosyncratic ADRs, dose-dependent toxicities, drug-drug interactions, immune-mediated adverse drug effects (IMADEs), and genetic susceptibility toxicities.
- Development of user-friendly interfaces for flexible data retrieval.
Main Results:
- The DITOP currently contains 1501 records, encompassing 618 distinct DITRPs, 529 drugs/ligands, and 418 toxicity terms.
- Experimentally confirmed interactions between proteins and drugs/metabolites leading to adverse effects are documented.
- Information on molecular mechanisms and cross-links to related resources is provided where available.
Conclusions:
- DITOP serves as a valuable, freely accessible resource for researchers studying drug-induced toxicity.
- The database enhances the understanding of adverse drug reactions and supports the development of safer therapeutics.
- DITOP promotes further investigation into the complex interplay between drugs, proteins, and toxicity.
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