Crosstalk Between Metabolic Reprogramming and Epigenetic Modifications in Colorectal Cancer: Mechanisms and Clinical...

Area of Science:

• Oncology
• Molecular Biology
• Metabolism

Background:

• Colorectal cancer (CRC) is a prevalent digestive tract malignancy.
• CRC development is characterized by significant metabolic reprogramming and epigenetic abnormalities.
• These alterations interact molecularly, promoting tumor cell progression.

Purpose of the Study:

• To systematically review metabolic pathway reprogramming in CRC.
• To elucidate key epigenetic abnormalities and their mechanisms in CRC.
• To explore the interplay between metabolic and epigenetic changes in CRC progression, diagnosis, and therapy.

Main Methods:

• Literature review focusing on metabolic reprogramming in CRC.
• Analysis of epigenetic abnormalities and their mechanisms in CRC.
• Synthesis of research on the mutual influence of metabolism and epigenetics in CRC.

Main Results:

• Cancer cells reprogram glucose, glutamine, and lipid metabolism for survival.
• Epigenetic modifications lead to gene expression imbalances, sustaining the malignant phenotype.
• Metabolites influence epigenetic enzymes, and epigenetic mechanisms regulate metabolic genes.

Conclusions:

• The interaction between metabolic reprogramming and epigenetic alterations is crucial in CRC.
• Understanding this interplay provides insights into novel diagnostic and therapeutic strategies for CRC.
• Targeting metabolism, epigenetics, or using combination therapies shows promise for CRC treatment.