Related Experiment Video
Updated: Jul 15, 2026
10:03
Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
Published on: November 18, 2022
New-onset diabetes after transplantation
David C Wheeler1, Andrew J Krentz
1Centre for Nephrology, Royal Free and University College Medical School, London.
Summary
New-onset diabetes after transplantation (NODAT) is a growing complication impacting organ transplant success. Understanding its causes, diagnosis, and management is crucial for patient and graft survival.
Area of Science:
- Nephrology
- Endocrinology
- Transplantation Medicine
Background:
- New-onset diabetes after transplantation (NODAT) is an increasingly prevalent complication following solid organ transplantation.
- NODAT significantly impacts long-term graft and patient survival rates.
- The rising incidence necessitates a comprehensive understanding of its multifaceted nature.
Purpose of the Study:
- To review the current understanding of the pathogenesis of NODAT.
- To outline diagnostic criteria and approaches for NODAT.
- To discuss evidence-based management strategies for NODAT.
Main Methods:
- Literature review of pathogenesis, diagnosis, and management of NODAT.
- Synthesis of data from clinical trials and observational studies.
- Expert consensus and guideline recommendations.
Main Results:
- NODAT pathogenesis involves immunosuppression, metabolic changes, and pre-existing risk factors.
- Early diagnosis relies on glucose monitoring and established diabetes criteria.
- Management includes lifestyle modifications, oral hypoglycemics, and insulin therapy.
Conclusions:
- NODAT is a critical post-transplant complication requiring vigilant monitoring.
- Multidisciplinary management is essential for optimizing outcomes.
- Further research into prevention and personalized treatment is warranted.
Related Concept Videos
01:22Diabetes Mellitus: Type 2 and Gestational
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
01:22Diabetes Mellitus: Overview and Type I Subtype
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
01:19Type I Diabetes III: Clinical Manifestations
Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
01:15Diabetes: Symptoms, Diagnosis, and Complications
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...
01:25Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
01:12Type I Diabetes I: Introduction
Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...