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Published on: February 3, 2012
Clinical heterogeneity in autoimmune acute liver failure
Norberto C Chavez-Tapia1, Julio Martinez-Salgado, Julio Granados
1Departamento de Gastroenterologia, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga #5. Col. Seccion XVI. Del. Tlalpan. CP 14000, Distrito Federal, Mexico. khavez@gmail.com
Aim:
To describe the outcome and prognosis in a cohort of patients with acute liver failure due to autoimmune hepatitis without liver transplantation.
Methods:
A retrospective trial was conducted in 11 patients with acute liver failure due to autoimmune hepatitis who attended the Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Demographic, biochemical and severity indexes, and treatment and outcome were assessed.
Results:
Among the 11 patients, with a median age of 31 years, 72% had inflammatory response syndrome, and six patients received corticosteroids. The mortality rate within four weeks was 56%, and the one-year survival was 27%. In the survivors, severity indexes were lower and 83% received corticosteroids.
Conclusion:
We observed a relatively high survival rate in patients with acute liver failure due to autoimmune hepatitis. This survival rate could be influenced by severity of the disease and/or use of corticosteroids.
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