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Updated: Jul 15, 2026

Isolation of Murine Lymph Node Stromal Cells
Published on: August 19, 2014
Lessons on immune tolerance from the monogenic disease APS1
Jason J DeVoss1, Mark S Anderson
1University of California San Francisco Diabetes Center, HSW1102, San Francisco, CA 94143-0540, USA. jdevoss@diabetes.ucsf.edu
Abstract:
Autoimmunity is a complex disease process that results from a breakdown in the ability of the immune system to discriminate self from non-self. One approach to unraveling how autoimmunity occurs is to study monogenic diseases, for which a single gene defect is responsible. Recent work on the monogenic autoimmune disease 'autoimmune polyglandular syndrome type 1' (APS1) and on the causal gene of this disorder--autoimmune regulator (AIRE)--is providing new lessons on how immune tolerance is maintained.
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