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Posterior pituitary function in Sheehan's syndrome.

Hulusi Atmaca1, Fatih Tanriverdi, Cumali Gokce

  • 1Department of Endocrinology, Zonguldak Karaelmas University Medical School, Zonguldak, Turkey.

European Journal of Endocrinology
|May 1, 2007
PubMed
Summary
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Patients with Sheehan's syndrome show impaired posterior pituitary function, specifically an increased thirst threshold. This neurohypophyseal dysfunction affects posterior pituitary function in Sheehan's syndrome patients.

Area of Science:

  • Endocrinology
  • Neuroscience

Background:

  • Sheehan's syndrome is a rare condition characterized by postpartum pituitary necrosis.
  • Posterior pituitary function is not well understood in patients with Sheehan's syndrome.

Purpose of the Study:

  • To investigate posterior pituitary function in patients with Sheehan's syndrome.
  • To assess the osmotic threshold for thirst in these patients.

Main Methods:

  • Water deprivation test and hypertonic saline infusion test were performed.
  • 27 patients with Sheehan's syndrome and 14 controls were included.
  • Patients were on adequate hormone replacement therapy.

Main Results:

  • 8 patients (29.6%) exhibited partial diabetes insipidus.

Related Experiment Videos

  • Maximal plasma osmolality was higher in patients than controls.
  • Maximal urine osmolality was lower in the partial diabetes insipidus group.

    • Conclusions:

    • Sheehan's syndrome is associated with impaired neurohypophyseal function.
    • The osmotic threshold for thirst is increased in patients with Sheehan's syndrome.
    • Ischemic damage may affect the thirst center.