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Related Experiment Videos

How microcirculation data have changed my clinical practice.

Gustavo Luiz Büchele1, Gustavo Adolfo Ospina-Tascon, Daniel De Backer

  • 1Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium.

Current Opinion in Critical Care
|May 1, 2007
PubMed
Summary
This summary is machine-generated.

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Microcirculation assessment, now feasible, impacts clinical practice. Studies reveal microcirculatory changes in critical illness, influencing outcomes and guiding therapeutic interventions for better patient prognosis.

Area of Science:

  • Critical care medicine
  • Physiology
  • Medical imaging

Background:

  • Microcirculation assessment has recently become clinically feasible.
  • Understanding microcirculation is crucial in disease states.

Purpose of the Study:

  • To review how microcirculation assessment has altered clinical practice.
  • To highlight the role of microcirculation in critical illness.

Main Methods:

  • Review of experimental data and recent advances in imaging techniques.
  • Analysis of microcirculation studies in critically ill patients.
  • Exploration of vasoreactivity tests and indirect blood flow measurements (laser Doppler, near-infrared spectroscopy).

Main Results:

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  • Microcirculation derangements are variable, unpredictable, and linked to organ dysfunction and patient outcomes.
  • Therapeutic interventions can improve microcirculation.
  • Drug effects on microcirculation and their mechanisms, particularly involving white blood cells, are being elucidated.
  • Bedside implementation of advanced imaging techniques remains challenging.

    • Conclusions:

    • Microcirculatory alterations are evident in shock states, notably septic shock, and possess prognostic value.
    • Microcirculation can be a target for therapeutic interventions.
    • While primarily in clinical investigation, bedside microcirculation assessment is becoming more encouraged.