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Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

Factitial pemphigus-like lesions.

Ali Taghavi Zonuz¹, Nathaniel Treister, Fahimeh Mehdipour

¹Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Medicina Oral, Patologia Oral Y Cirugia Bucal

|May 1, 2007

Summary

Factitious disease affecting the maxillofacial region is rare. This case highlights self-inflicted oral and facial lesions misdiagnosed as pemphigus vulgaris, emphasizing the need for considering factitious disorders in differential diagnoses.

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Published on: October 12, 2012

Area of Science:

Oral and Maxillofacial Surgery
Dermatology
Psychiatry

Background:

Factitious disease, characterized by intentional self-harm, rarely affects the maxillofacial region.
Reported manifestations include nasal ulceration, facial emphysema, and oral lesions.
Differential diagnosis of oral vesiculobullous disorders is complex.

Observation:

A young woman presented with unilateral bullous, ulcerative oral, and erythematous facial lesions.
Initial diagnosis was pemphigus vulgaris.
Lesions were later determined to be self-inflicted.

Findings:

This clinical presentation of factitious disease in the maxillofacial region is novel.
The case demonstrates a unique manifestation of self-inflicted injuries.
The patient's lesions mimicked autoimmune blistering diseases.

Implications:

This case expands the known spectrum of factitious disease presentations.
Clinicians should consider factitious disorder in the differential diagnosis of unexplained oral and facial lesions.
Early recognition of self-inflicted injuries is crucial for appropriate management and treatment.