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Updated: Jul 15, 2026
06:55
Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
[Changes in the subsystems of haemostasis during normal pregnancy]
Akusherstvo I Ginekologiia
|May 2, 2007
Summary
Pregnancy involves complex changes in haemostasis, yet the balance between coagulation and fibrinolysis is maintained. Despite a procoagulant state, venous thromboembolism (VTE) risk remains low.
Area of Science:
- Physiology
- Hematology
Context:
- Haemostasis is a dynamic, self-regulated system crucial for maintaining equilibrium.
- Pregnancy significantly alters haemostatic systems, introducing complex physiological changes.
- Understanding these alterations is vital for managing pregnancy-related risks.
Purpose:
- To elucidate the complex haemostatic changes during normal pregnancy.
- To investigate the preservation of haemostatic balance despite these changes.
- To analyze the relationship between haemostatic alterations and venous thromboembolism (VTE) incidence.
Summary:
- During normal pregnancy, haemostasis undergoes intricate modifications involving both procoagulant and anticoagulant factors.
- Despite these dynamic shifts and a generally procoagulant tendency, the overall haemostatic balance and the coagulation/fibrinolysis ratio are preserved.
- The incidence of VTE remains relatively low, suggesting effective compensatory mechanisms.
Impact:
- Provides insights into the physiological adaptations of haemostasis during pregnancy.
- Highlights the resilience of the haemostatic system in maintaining balance.
- Contributes to understanding the low incidence of VTE in pregnant individuals despite procoagulant changes.
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