Petrous apex aspergillosis as a long-term complication of cholesterol granuloma

Jean Anderson Eloy1, Joshua B Bederson, Eric E Smouha

  • 1Department of Otolaryngology-Head and Neck Surgery, Mount Sinai School of Medicine, New York, New York 10029, USA. Jean.Anderson.Eloy@gmail.com

The Laryngoscope
|May 2, 2007
PubMed

Insights

Petrous apex aspergillosis is a rare, severe infection. Early aggressive surgery is crucial for survival in this devastating condition, especially when it occurs after prior cyst drainage.

Area of Science:

  • Otolaryngology
  • Infectious Diseases
  • Neurosurgery

Background:

  • Petrous apex aspergillosis is an exceptionally rare and severe infection.
  • Previous cases stemmed from chronic Aspergillus otitis media.
  • This condition carries a high mortality risk.

Observation:

  • A unique case of petrous apex aspergillosis is presented.
  • This occurred years after surgical drainage of a petrous apex granuloma cyst.
  • This presentation differs from previously reported cases.

Findings:

  • Aspergillus infection can manifest in the petrous apex long after initial treatment for related conditions.
  • The infection's latency highlights the need for vigilance in patients with a history of petrous apex pathology.

Implications:

  • Prompt and aggressive surgical intervention is recommended for petrous apex aspergillosis.
  • Early surgical therapy may significantly improve patient survival rates.
  • This case broadens the understanding of potential etiologies for petrous apex aspergillosis.

Related Concept Videos

Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Fungal Phylum Ascomycota01:28

Fungal Phylum Ascomycota

Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
Esophageal Achalasia01:27

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...