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Author Spotlight: Identification and Isolation of Quiescent Leukemia Stem Cells from Zebrafish T-ALL
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Cells, cells, and more cells.
M Tariq Bhatti1, Katherine E Gres, Virginia B Petitto
1Department of Ophthalmology, Duke University Eye Center and Duke University Medical Center, Durham, North Carolina 27710, USA.
Survey of Ophthalmology
|May 3, 2007
Summary
A paraneoplastic syndrome caused optic nerve swelling and vitritis in a patient with small-cell lung cancer. Treatment of the cancer resolved these neurological symptoms, highlighting the importance of identifying paraneoplastic syndromes.
Area of Science:
- Neurology
- Ophthalmology
- Oncology
Background:
- Paraneoplastic syndromes can manifest with diverse neurological and ocular symptoms.
- Small-cell lung carcinoma is a known cause of paraneoplastic neurological disorders.
Observation:
- A 64-year-old woman presented with bilateral optic nerve swelling, vitritis, and cerebrospinal fluid pleocytosis.
- Imaging revealed a left lung lesion consistent with small-cell lung carcinoma.
- The patient tested positive for anti-CV2 (anti-CRMP-5) antibodies.
Findings:
- The patient's symptoms resolved after chemoradiation therapy for the lung carcinoma.
- This case illustrates a paraneoplastic syndrome affecting the optic nerves and vitreous.
Implications:
- Early diagnosis and treatment of the underlying malignancy are crucial for managing paraneoplastic syndromes.
- Anti-CV2 (anti-CRMP-5) antibodies are a potential biomarker for paraneoplastic neurological disorders associated with lung cancer.
- Understanding the pathophysiology of paraneoplastic syndromes aids in differential diagnosis and patient management.
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