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Aqueous humor and serum concentration of hydroxyproline in pseudoexfoliation syndrome
Ramazan Yagci1, Ibrahim Ersöz, Bahri Aydin
1Department of Ophthalmology, Medical School, Fatih University, Ankara, Turkey. ramazanyagci@yahoo.com
Purpose:
To determine the concentration of hydroxyproline (Hyp) in aqueous humor and serum samples of patients with and without pseudoexfoliation (PEX).
Patients And Methods:
Aqueous humor and serum Hyp levels were measured in cataract patients. Patients were divided into PEX and control groups. Samples were obtained from 27 cataract patients with PEX and 25 cataract patients without PEX. Patients had no elevated intraocular pressure or glaucoma. Hyp concentration was determined spectrophotometrically.
Results:
Mean Hyp concentration in the PEX aqueous (0.86+/-0.27 mg/L) and serum (40.8+/-6.14 mg/L) samples was significantly higher than that measured in the control aqueous (0.56+/-0.2 mg/L) and serum (34.51+/-6.82 mg/L) samples, respectively (P<0.001, P=0.001). No significant correlation could be found between aqueous humor and serum Hyp concentrations.
Conclusions:
The higher levels of Hyp could be a sign of increased collagen turnover in PEX syndrome.
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