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Updated: Jul 15, 2026

State of the Art Cranial Ultrasound Imaging in Neonates
Published on: February 2, 2015
Optical tomography of the neonatal brain
Jeremy C Hebden1, Topun Austin
1Department of Medical Physics & Bioengineering, University College London, Gower Street, London, WC1E 6BT, UK. jem@medphys.ucl.ac.uk
Abstract:
A new method of assessing neurological function and pathology in the newborn infant is being developed based on the transmission of near-infrared light across the brain. Absorption by blood over a range of wavelengths reveals a strong dependency on oxygenation status, and measurements of transmitted light enable the spatial variation in the concentrations of the oxygenated and de-oxygenated forms of hemoglobin to be derived. Optical tomography has so far provided static three-dimensional maps of blood volume and oxygenation as well as dynamic images revealing the brain's response to sensory stimulation and global hemodynamic changes. The imaging modality is being developed as a safe and non-invasive tool that can be utilized at the cotside in intensive care. Optical tomography of the healthy infant brain is also providing a means of studying neurophysiological processes during early development and the potential consequences of prematurity.
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