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Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors
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Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors

Published on: September 13, 2013

GPCR targeted library design: novel dopamine D3 receptor ligands

A Böcker1, B C Sasse, M Nietert

  • 1Institute of Organic Chemistry & Chemical Biology/CMP/ZAFES, Johann Wolfgang Goethe-University, Siesmayerstr. 70,D-60323 Frankfurt a.M., Germany.

Chemmedchem
|May 5, 2007
PubMed
Summary

No abstract available in PubMed .

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G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...