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Sulfa drugs as model cocrystal formers
1Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa. Mino.Caira@uct.ac.za
Molecular Pharmaceutics
|May 5, 2007
Summary
This review explores cocrystallization of sulfonamide drugs with other molecules. Sulfadimidine serves as a model, highlighting solid-state chemistry, polymorphism, and solvate formation in sulfa drug cocrystals.
Area of Science:
- Solid-state chemistry
- Pharmaceutical science
- Crystallography
Background:
- Sulfonamide drugs are important pharmaceutical agents.
- Cocrystallization offers a strategy to modify drug properties.
- Understanding the solid-state chemistry of sulfonamide cocrystals is crucial.
Purpose of the Study:
- To review cocrystallization strategies involving sulfonamide drugs.
- To focus on the use of other drug molecules as cocrystallization partners.
- To discuss the physicochemical phenomena associated with sulfonamide cocrystals.
Main Methods:
- Review of earlier exploratory studies.
- Systematic investigation of cocrystal preparation.
- Solid-state cogrinding of individual components.
- Selective cocrystal formation in competition experiments.
- Exchange reactions.
Main Results:
- Sulfadimidine was identified as a prominent model cocrystal former.
- Cocrystals and salts of sulfa drugs exhibit polymorphism.
- Isostructurality and solvate formation are common phenomena.
- Cocrystallization impacts the physicochemical properties of sulfonamide drugs.
Conclusions:
- Cocrystallization is a valuable approach for sulfonamide drug development.
- The solid-state chemistry of sulfonamide cocrystals is complex and multifaceted.
- Further research into sulfonamide cocrystals is warranted due to their medicinal potential and unique properties.
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