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Related Experiment Video

Updated: Jul 15, 2026

Formation of Human Prostate Epithelium Using Tissue Recombination of Rodent Urogenital Sinus Mesenchyme and Human Stem Cells

Formation of Human Prostate Epithelium Using Tissue Recombination of Rodent Urogenital Sinus Mesenchyme and Human Stem Cells

Published on: June 22, 2013

Epithelial phenotypes in the developing human prostate.

Guy Letellier¹, Marie-José Perez, Mokrane Yacoub

¹Service de Pédiatrie, Centre Hospitalier Universitaire-Université de Poitiers, Poitiers, France.

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society

|May 5, 2007

Summary

Most fetal prostate cells are transiently amplifying (TA) cells, characterized by specific cytokeratin (CK) expression and high proliferation. These findings suggest TA cells play a key role in prostate development.

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Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

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Published on: November 22, 2019

Area of Science:

Urology
Developmental Biology
Cell Biology

Background:

Transiently amplifying (TA) cells, marked by basal and luminal cytokeratin (CK) coexpression, high proliferation, and low p27, are known in adult prostates.
Their role in prostate development is currently unknown.

Purpose of the Study:

To investigate the presence and phenotype of TA cells in the developing fetal prostate.
To compare fetal prostatic cell markers with those in adult prostates.

Main Methods:

Immunohistochemical analysis of fetal prostates (13-42 weeks gestation) and adult normal prostates.
Tissue microarray construction for 40 fetal and 10 adult prostate samples.
Evaluation of cytokeratins (CKs 5/6, 18, 19), p63, Ki67, p27, epidermal growth factor receptor (EGFR), Bcl2, and androgen receptor (AR).

Main Results:

Fetal prostate cells, in both solid buds and basal compartments, expressed p63, CK5/6, CK19, CK18, Bcl2, and EGFR, and were p27 negative.
Fetal luminal cells also expressed CK19, EGFR, and Bcl2, lacking p27.
Adult luminal cells showed diffuse AR and p27 expression, with absent CK19, Bcl2, and EGFR. Proliferation was high in fetal glands but restricted to basal cells in adults.

Conclusions:

The majority of fetal prostatic epithelial cells exhibit the TA cell phenotype.
These findings suggest that TA cells are crucial for regulating prostate development.