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Published on: February 3, 2023
Solid dispersion adsorbates for enhancement of dissolution rates of drugs
Deepti1, Harish Dureja, A K Madan
1Faculty of Pharmaceutical Sciences, M.D. University, Rohtak, India.
Abstract:
Amalgamation of solid dispersion and melt adsorption technologies was utilized for enhancing the dissolution rate of poorly soluble drugs. Glibenclamide was employed as a model drug. PEG6000 and Gelucire44/14 were used as hydrophilic carriers for the preparation of solid dispersions, and lactose was utilized as an adsorbent for the preparation of solid dispersion adsorbates. A high dissolution rate of solid dispersion adsorbates was observed when compared to solid dispersions alone and one of the marketed products.
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