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Updated: Jul 15, 2026

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
Published on: April 21, 2022
[Influence of DNA damage on fertilizing capacity of spermatozoa]
Jacek Sikora1, Bartosz Kempisty, Piotr Jedrzejczak
1Katedra i Zakład Biochemii i Biologii Molekularnej Akademii Medycznej im. K. Marcinkowskiego w Poznaniu.
Abstract:
DNA damage in the male germ line cells is correlated with male infertility. Nuclear DNA damage in mature sperm includes single strand nicks and double strand breaks that can arise as a consequence of errors in chromatin rearrangement during spermiogenesis, abortive apoptosis, and oxidative stress. Methods of assisted reproduction may be connected with a risk of the using of sperm with impaired DNA integrity that can lead to spontaneous abortion or delivery of a child with congenital abnormalities.
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