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Related Concept Videos

Drug Products: Biologics, Biosimilars and Interchangeables01:28

Drug Products: Biologics, Biosimilars and Interchangeables

Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
Bioequivalence studies: Biowaivers01:13

Bioequivalence studies: Biowaivers

In certain scenarios, in vitro dissolution tests can replace in vivo bioequivalence studies. This is particularly true when a drug product, though available in varying strengths, maintains proportional similarity in its active and inactive ingredients. In such cases, the need for in vivo bioequivalence studies for lower strength variants may be waived, provided dissolution tests and in vivo studies on the highest strength yield satisfactory results.Bioequivalence can be indicated through...
Production of Pharmaceuticals01:30

Production of Pharmaceuticals

Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under sterile, tightly...
Production of Biopesticides01:18

Production of Biopesticides

Biopesticides offer a sustainable alternative to chemical pesticides, utilizing microbial agents to control agricultural pests. Bacillus thuringiensis (Bt) is a widely employed bacterium known for its potent insecticidal activity. Bt biopesticides are favored for their specificity to insect pests, minimal environmental impact, and natural degradability.Mechanism of Bt Toxin Action Bt produces insecticidal crystal (Cry) proteins during its sporulation phase. These proteins form parasporal...
Bioequivalence of Drugs: Drugs with Multiple Indications01:09

Bioequivalence of Drugs: Drugs with Multiple Indications

The concept of therapeutic equivalence (TE) in drugs with multiple indications is complex. A generic drug may be therapeutically equivalent to a brand-name product for one specific indication, but this doesn't necessarily mean it's equivalent for all other indications. Evidence of TE in one patient group and bioequivalence shown in healthy volunteers can support—but not confirm—TE for other indications. However, definitive proof requires individual clinical studies for each indication due to...
Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though pharmacologically...

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Pooled shRNA Library Screening to Identify Factors that Modulate a Drug Resistance Phenotype
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Indian Biotech Bazaar: a swot analysis.

Abhishek Kumar1

  • 1Amity Institute of Biotechnology, Noida, India. kumarabhishek_13@yahoo.co.in

Biotechnology Journal
|May 8, 2007
PubMed
Summary

Biotechnology, a life science technique, manipulates organisms for global welfare in agriculture, medicine, and food. This rapidly emerging field offers hope for food, health, and environmental sustainability.

Area of Science:

  • Life sciences
  • Biotechnology applications in agriculture, medicine, and food sciences

Background:

  • Biotechnology defined as organism manipulation for societal benefit.
  • Combines genetics, biochemistry, microbiology, cell biology, IT, chemical engineering, and robotics.
  • Encompasses food processing, tissue culture, plant development, recombinant therapeutics, and diagnostics.

Purpose of the Study:

  • To highlight the significance of biotechnology as a 'technology of hope'.
  • To present the economic impact and growth of the biotechnology sector in India.
  • To outline the key segments within the Indian biotechnology market.

Main Methods:

  • Market analysis of biotechnology sales in India from 1997 to 2010 projections.
  • Segmentation of the Indian biotechnology market by product/service category.

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  • Overview of policy and investment trends facilitating foreign capital.

    • Main Results:

    • Biotechnology employs over 10,000 people in India, generating significant annual revenue.
    • Projected market growth from Rs. 70 billion in 2000 to Rs. 240 billion by 2010.
    • Human health products dominate the Indian market (60%), followed by agribiotech/veterinary (25%).

    Conclusions:

    • Biotechnology is a crucial, rapidly growing sector with immense potential for sustainability.
    • The Indian biotechnology market shows strong growth, driven by human health and agriculture.
    • Policy revisions aim to boost foreign investment and further develop the industry.