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Biphosphonate-associated osteonecrosis can be controlled by nonsurgical management
Lucio Montebugnoli1, Laura Felicetti, Davide Bartolomeo Gissi
1Department of Oral Science, University of Bologna, Bologna, Italy. lucio.montebugnoli@unibo.it
Summary
This study compared surgical versus antibiotic treatments for jaw osteonecrosis caused by biphosphonate medications. Long-term antibiotic therapy showed comparable results to surgery for managing this condition.
Area of Science:
- Oral and Maxillofacial Surgery
- Pharmacology
- Oncology
Background:
- Biphosphonate-associated osteonecrosis of the jaw (ONJ) is a serious complication.
- Exposed bone areas in ONJ present significant treatment challenges.
Purpose of the Study:
- To compare the efficacy of surgical intervention versus antibiotic treatment for jaw ONJ.
- To evaluate the dimensional changes in necrotic bone areas following different treatment modalities.
Main Methods:
- Sixteen patients with jaw ONJ and exposed bone were divided into two groups.
- Group 1 (7 patients): superficial or radical surgical therapy.
- Group 2 (9 patients): antibiotic treatment.
Main Results:
- A slight reduction in necrotic areas was observed in 5/7 surgical patients and 7/9 antibiotic patients.
- No significant difference in dimensional change of exposed bone between treatment groups.
- Preliminary findings suggest comparable outcomes for both approaches.
Conclusions:
- Neither surgical nor antibiotic treatment significantly influenced dimensional changes in exposed bone.
- Long-term antibiotic administration may offer a viable nonsurgical approach for managing biphosphonate-associated osteonecrosis.
- Further research is warranted to confirm these preliminary findings.
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