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Updated: Jul 15, 2026
06:55
Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions
Published on: June 7, 2020
Chaperonopathies by defect, excess, or mistake
Alberto J L Macario1, Everly Conway de Macario
1University of Maryland Biotechnology Institute, Center of Marine Biotechnology, 701 E. Pratt Street, Baltimore, MD 21202, USA. macario@umbi.umd.edu
Annals of the New York Academy of Sciences
|May 8, 2007
Summary
Chaperonopathies are diseases caused by defective molecular chaperones, impacting all ages. Research is expanding into chaperone networks, therapies, diagnostics, and treatments targeting these "sick chaperones".
Area of Science:
- Molecular biology
- Cellular stress response
- Chaperonology
Background:
- Extensive research exists on stress proteins and molecular chaperones.
- Information is fragmented across literature and databases.
- The concept of chaperone pathology (chaperonopathies) has emerged.
Purpose of the Study:
- To discuss recent findings on chaperonopathies.
- To highlight emerging fields within chaperonology.
Main Methods:
- Review of existing literature and databases.
- Discussion of identified pathological conditions linked to defective chaperones.
Main Results:
- Chaperonopathies manifest at all ages, with genetic forms appearing early and acquired forms later.
- Defective chaperones play an etiological role in various diseases.
Conclusions:
- Chaperonopathies represent a significant area of study.
- Future research will focus on extracellular chaperones, networks, chaperonotherapy, diagnostics, and antichaperone agents.
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