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Updated: Jul 15, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Periorbital cutaneous neonatal lupus.

Rani M Cooper¹, David F Butler, Fred Ghali

¹Department of Medicine, Division of Dermatology, Scott and White Memorial Hospital and Clinic, 409 Adams Street, Temple, TX 76508, USA.

|May 8, 2007

Summary

This study highlights a rare facial rash in infants, often linked to maternal autoimmune conditions like Sjögren syndrome. Early diagnosis and treatment, including sun protection, can effectively manage this photosensitive eruption.

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Area of Science:

Pediatric Dermatology
Neonatal Immunology
Maternal-Fetal Medicine

Background:

Infantile periorbital eruptions can present as photosensitive facial dermatitis.
These rashes may be associated with maternal autoimmune diseases, particularly Sjögren syndrome.
Anti-SSA antibodies are frequently detected in affected infants and their mothers.

Observation:

Three infant girls presented with similar annular, polycyclic, erythematous, scaly plaques on the face, predominantly periorbital.
All infants had positive anti-SSA antibodies, with one also testing positive for anti-SSB antibodies.
Maternal evaluations revealed positive anti-SSA antibodies in two mothers, with one having a history of Sjögren syndrome.

Findings:

Infant facial eruptions showed a strong association with maternal anti-SSA antibody positivity.

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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Skin lesions responded to topical treatments such as desonide cream or tacrolimus ointment, combined with sun protection.

Cardiac evaluations and electrocardiograms in the infants were normal, ruling out significant congenital heart block.

Implications:

Maternal anti-SSA antibody screening should be considered in infants with persistent photosensitive facial rashes.
Prompt diagnosis and management, including photoprotection, can lead to favorable dermatological outcomes.
This finding underscores the importance of understanding transplacental antibody transfer in neonatal skin conditions.