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[Cutaneous manifestations during treatment with TNF-alpha blockers: 11 cases]

D Lebas1, D Staumont-Sallé, E Solau-Gervais

  • 1Clinique de Dermatologie, Hôpital Claude Huriez, CHRU Lille, Lille Cedex.

Annales De Dermatologie Et De Venereologie
|May 8, 2007
PubMed
Abstract

Insights

Tumor necrosis factor-alpha (TNFα) blockers can cause various skin reactions. Dermatologists should monitor patients for these potential adverse dermatological effects during treatment.

Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Context:

  • Tumor necrosis factor-alpha (TNFα) blockers are increasingly used in dermatology.
  • Adverse dermatological effects of TNFα blockers are not well-documented.
  • Understanding these side effects is crucial for patient safety.

Purpose:

  • To report the spectrum of cutaneous adverse events observed in patients treated with TNFα blockers.
  • To raise awareness among dermatologists regarding potential skin reactions.

Summary:

  • A retrospective study identified eleven patients experiencing cutaneous reactions while on TNFα blockers.
  • Observed reactions included lupus syndrome, vasculitis, pustulosis, psoriasis, atopic dermatitis, lichenoid rash, purpuric capillaritis, and melanoma.
  • Delayed skin rash was also noted.

Impact:

  • Highlights the diverse range of potential dermatological side effects associated with TNFα blockers.
  • Emphasizes the need for dermatologists to be vigilant for these adverse reactions.
  • Suggests further research into physiopathological mechanisms and prospective studies for better management.

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