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Published on: May 10, 2024
[Panniculitis induced by interferon beta-1a vascular toxicity].
A Soria1, E Maubec, M-C Henry-Feugeas
1Service de Dermatologie, Hôpital Bichat, Assistance Publique Hôpitaux de Paris, Université Paris 7-Denis-Diderot.
Annales De Dermatologie Et De Venereologie
|May 8, 2007
Summary
Panniculitis, a rare skin reaction, can occur after subcutaneous interferon beta injections for multiple sclerosis. Magnetic resonance imaging (MRI) aids diagnosis, and managing this adverse event may involve treatment adjustments.
Area of Science:
- Immunology
- Neurology
- Dermatology
Context:
- Interferon beta-1b is a first-line treatment for relapsing-remitting multiple sclerosis.
- Cutaneous reactions at injection sites are common, but panniculitis is rare.
- Two cases of severe panniculitis following subcutaneous interferon beta injections are presented.
Purpose:
- To describe two cases of panniculitis induced by subcutaneous interferon beta.
- To highlight diagnostic challenges and potential imaging utility.
- To discuss management strategies for this rare adverse event.
Summary:
- Two women with multiple sclerosis developed severe, painful panniculitis at interferon beta injection sites.
- Histology revealed vasculitis and thrombosis; MRI showed avascular necrosis.
- Management included interferon withdrawal and surgical debridement in one case, with successful reintroduction in both.
Impact:
- These cases suggest vascular toxicity of interferon beta may contribute to panniculitis.
- Magnetic resonance imaging (MRI) can be a valuable diagnostic tool.
- Management options include temporary withdrawal, site rotation, and alternative administration routes.
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