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Updated: Jul 15, 2026
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Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
Published on: August 19, 2021
Sentinel node mapping during laparoscopic distal gastrectomy for gastric cancer
E Orsenigo1, V Tomajer, S Di Palo
1Department of Surgery, San Raffaele Scientific Institute, University Vita-Salute, Milan, Italy. orsenigo.elena@hsr.it
Surgical Endoscopy
|May 8, 2007
Summary
Sentinel node mapping using blue dye during laparoscopic distal gastrectomy is feasible for early gastric cancer, achieving 100% accuracy. However, its accuracy is less satisfactory for advanced gastric cancer, requiring further research.
Area of Science:
- Surgical Oncology
- Gastroenterology
- Diagnostic Imaging
Background:
- Gastric cancer management involves assessing lymph node metastasis.
- Sentinel lymph node (SN) biopsy is a crucial staging technique.
- Minimally invasive surgery like laparoscopic distal gastrectomy is increasingly used.
Purpose of the Study:
- To evaluate the feasibility and accuracy of SN mapping using endoscopic submucosal blue dye injection.
- To assess the diagnostic performance of this technique during laparoscopic distal gastrectomy for gastric cancer.
Main Methods:
- Prospective enrollment of 34 gastric adenocarcinoma patients without distant metastasis.
- Endoscopic submucosal injection of 2% patent blue dye around the primary tumor site.
- Identification and removal of blue-stained SNs followed by laparoscopic distal gastrectomy with lymphadenectomy.
Main Results:
- SNs were detectable in 80% of patients (27/34).
- Overall accuracy for diagnosing lymph node status was 74%.
- In early gastric cancer (n=18), SN mapping demonstrated 100% sensitivity for detecting nodal metastases.
Conclusions:
- Blue dye SN mapping is a feasible and accurate tool for early-stage gastric cancer.
- The method's accuracy is insufficient for more advanced gastric cancer.
- Further studies are needed to validate and refine SN mapping techniques, including tracer selection.
