[Severe microbial keratitis: report of 100 cases]

Area of Science:

• Ophthalmology
• Microbiology
• Infectious Diseases

Context:

• Microbial keratitis is a significant cause of visual impairment and blindness worldwide.
• Understanding predisposing factors and causative agents is crucial for effective treatment.
• This study investigates severe microbial keratitis cases in Tunisia.

Purpose:

• To identify predisposing factors for severe microbial keratitis.
• To analyze clinical presentations and microbiological findings.
• To evaluate treatment strategies and visual outcomes.

Summary:

• A study of 100 hospitalized patients revealed ocular surface pathology, trauma, surgery, and contact lens wear as key predisposing factors.
• Bacterial and fungal infections were identified, with Gram-positive bacteria being most common.
• Broad-spectrum topical antibiotics were widely used, achieving a 53.8% success rate; surgery was required in 25.8% of cases.

Impact:

• Early and appropriate management of microbial keratitis is essential for improving patient prognosis.
• 81% of patients maintained or improved visual acuity, but 8% experienced eye loss.
• Findings highlight the need for timely and tailored interventions to mitigate severe visual consequences.