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Published on: June 11, 2017
Insulin-like growth factor type-1 receptor transactivation in vasoactive peptide and oxidant-induced signaling
Zeina M Azar1, Mohamad Z Mehdi, Ashok K Srivastava
1Montreal Diabetes Research Centre, Centre hospitalier de l'Université de Montréal (CHUM)- Angus Campus and Department of Medicine, Université de Montréal, 2901, Rachel East, Montreal, QC H1W 4A4, Canada.
Abstract:
Transactivation of epidermal growth factor receptor (EGFR) is a well-documented mechanism by which vasoactive peptides and H2O2 elicit their cellular responses. However, a role for the insulin-like growth factor type-1 receptor (IGF-1R) transactivation in mediating the effects of angiotensin II (Ang II) and H2O2 in vascular smooth muscle cells from different artery types have also been recently recognized. By using a series of pharmacological inhibitors of various growth factor receptor tyrosine kinases and a direct analysis of the phosphorylation status of the beta-subunit of IGF-1R, a requirement of this growth factor receptor in Ang II and H2O2 response has been demonstrated. This review discusses some of the studies that highlight the importance of IGF-1R transactivation in mediating Ang II- and H2O2-induced mitogen-activated protein kinase and protein kinase B signaling pathways.
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