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Systemic inflammation and mortality in chronic obstructive pulmonary disease.
1James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St. Paul,s Hospital, Vancouver, Canada. dsin@mrl.ubc.ca
Canadian Journal of Physiology and Pharmacology
|May 10, 2007
Summary
Systemic inflammation, measured by C-reactive protein (CRP), is linked to cardiovascular disease and cancer in chronic obstructive pulmonary disease (COPD) patients. Elevated CRP predicts mortality and extra-pulmonary complications in COPD.
Area of Science:
- Pulmonary Medicine
- Cardiology
- Oncology
Background:
- Chronic obstructive pulmonary disease (COPD) is associated with increased risks of cardiovascular diseases and cancer.
- Systemic inflammation is a common feature of COPD and is hypothesized to link COPD to these comorbidities.
Purpose of the Study:
- To investigate the role of systemic inflammation in mediating extra-pulmonary complications of COPD.
- To examine the predictive value of baseline C-reactive protein (CRP) levels for cardiovascular events and cancer in COPD patients.
Main Methods:
- Analysis of baseline CRP levels in COPD patients.
- Longitudinal follow-up (7-8 years) to assess incidence of cardiovascular events, cancer-specific mortality, and all-cause mortality.
Main Results:
- Baseline CRP levels were significantly associated with the incidence of cardiovascular events.
- Elevated CRP predicted cancer-specific mortality and all-cause mortality over the follow-up period.
- These findings support a temporal relationship between systemic inflammation and COPD comorbidities.
Conclusions:
- Systemic inflammation, indicated by CRP, plays a crucial role in the development of cardiovascular disease and cancer in COPD patients.
- Systemic inflammation contributes significantly to the overall morbidity and mortality observed in COPD.
- Targeting systemic inflammation may be a potential strategy to reduce extra-pulmonary complications in COPD.
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