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A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
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Overexpression of Pim-1 in head and neck squamous cell carcinomas

Ulf Henning Beier1, Jan Bernd Weise, Martin Laudien

  • 1Department of Pediatrics, University of Illinois at Chicago, Chicago, IL 60612, USA.

International Journal of Oncology
|May 10, 2007
PubMed

Insights

Pim-1 protein is overexpressed in most head and neck squamous cell carcinomas (HNSCC), suggesting its functional role in tumor development. This finding could lead to more targeted HNSCC therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Head and neck squamous cell carcinomas (HNSCC) have limited treatment outcome improvements.
  • Lack of individualized therapy based on tumor biology is a key challenge.

Purpose of the Study:

  • To identify differentially expressed genes in HNSCC.
  • To investigate the role of Pim-1 in HNSCC development.

Main Methods:

  • Differential display of mRNA from HNSCC and normal cells.
  • Northern hybridization for expression confirmation.
  • Immunohistochemistry for Pim-1 protein analysis.

Main Results:

  • A 127-bp fragment homologous to Pim-1 mRNA was overexpressed in HNSCC.
  • Pim-1 protein was overexpressed in 98% of invasive HNSCC.
  • Pim-1 expression showed a near-significant correlation with histological grade in primary tumors and metastases.

Conclusions:

  • Pim-1 is frequently overexpressed in HNSCC.
  • Absence of Pim-1 in normal epithelium suggests a functional role in HNSCC.
  • Pim-1 may be a potential therapeutic target for HNSCC.

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