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Updated: Jul 15, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
B cells: no longer the nondominant arm of multiple sclerosis
Eric C Klawiter1, Anne H Cross
1Department of Neurology, Washington University School of Medicine, Box 8111, 660 S. Euclid Avenue, Saint Louis, MO 63110, USA. klawitere@neuro.wustl.edu
Abstract:
The role B cells and humoral immunity play in multiple sclerosis (MS) is continually evolving. Recent discoveries include advances in lesion classification, identification of B cell clonal expansion in the central nervous system with evidence of antigen targeting, identification of chemokines in MS lesions, and expansion of information on the roles of autoantibodies and complement. Strong indications are accumulating that a greater degree of humoral dysfunction may lead to worsened long-term prognosis in MS. Effects of established MS treatments on B cells and their products have been further defined. Treatments that specifically target B cells are being implemented and hold promise.
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